Efficient procedures for the large-scale preparation of (1S,2S)-trans-2-methoxycyclohexanol, a key chiral intermediate in the synthesis of tricyclic β-lactam antibiotics

Autor:	David Noble, Stanley M. Roberts, Graham Webb, Tino Rossi, Hugh Marley, Michael J. Dawson, Yam To Ip, Paul Stead, Elisabetta Piga, Mahmoud Mahmoudian
Rok vydání:	1996
Předmět:	Inorganic Chemistry chemistry.chemical_classification chemistry.chemical_compound Resolution (mass spectrometry) Chemistry Yield (chemistry) Organic Chemistry Lactam Organic chemistry Physical and Theoretical Chemistry Enantiomeric excess Catalysis Tricyclic
Zdroj:	Tetrahedron: Asymmetry. 7:2247-2250
ISSN:	0957-4166
DOI:	10.1016/0957-4166(96)00279-0
Popis:	Enzymatic and chemical resolution methods suitable for preparation of multi-kg quantities of (+)-(1S,2S)-2-methoxycyclohexanol from (+/−) trans-2-methoxycyclohexanol have been developed. The enzymatic resolution was found to offer a particularly simple process affording the resolved product in good yield and excellent enantiomeric excess and has now been operated consistently on a manufacturing scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf9b673aa258ba58da2a899e9c70b5f3 https://doi.org/10.1016/0957-4166(96)00279-0 Zobrazit plný text záznamu Full Text from ScienceDirect