EVALUATION OF GASTROPROTECTIVE POTENTIAL OF CAJANUS CAJAN SEEDS EXTRACT ON ETHANOL-INDUCED GASTRIC ULCER IN ALBINO RATS
| Autor: | null AZUBUIKE, NKIRUKA C, null B. AMARA UDEMBA |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Asian Journal of Pharmaceutical and Clinical Research. :114-118 |
| ISSN: | 2455-3891 0974-2441 |
| Popis: | Objective: The present study was undertaken to evaluate the gastroprotective potential of Cajanus cajan seed aqueous extract (CCSE) on experimentally induced gastric ulcer in albino rats. Methods: Preliminary acute toxicity study was conducted to determine the oral median lethal dose (LD50). Twenty (20) male rats divided into 5 groups (A-E) of 4 animals each were used. Group A (normal control) and B (ulcer model) received 10ml/kg distilled water. Groups C, D and E received Cimetidine (100mg/kg b.w intraperitoneally), 250mg/kg and 500mg/kg b.w of CCSE orally respectively, once daily for seven (7) days. On Day 8, gastric ulcers were induced in groups B – E using 80% ethanol (1ml/rat) prior to sacrifice. Ulcer indices were determined on excised stomach tissues prior to further processing for histological examination. Results: The LD50 of CCSE is greater than 5g/kg b.w. Cimetidine and CCSE treatments showed statistically significant decrease (p |
| Databáze: | OpenAIRE |
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