Copper-catalyzed tandem annulation of 2-alkynoyl-2′-iodo-1,1′-biphenyls with isocyanoacetates: a rapid access to pyrrole-fused tetracyclic skeletons

Autor:	Wei Zhou, Kaifu Wu, Yifan Ouyang, Qian Cai
Rok vydání:	2021
Předmět:	Biphenyl chemistry.chemical_compound Annulation chemistry Tandem Organic Chemistry Rapid access Copper catalyzed Combinatorial chemistry Cycloaddition Catalysis Pyrrole
Zdroj:	Organic Chemistry Frontiers. 8:2456-2460
ISSN:	2052-4129
Popis:	An efficient and convenient synthesis of pyrrole-fused tetracyclic skeletons is presented. In this protocol using CuI as a catalyst, 1,1′-biphenyl substrates with 2-alkynoyl and 2′-iodo groups react with isocyanoacetates to provide 7-membered cyclic ketones fused with pyrrole and biphenyl rings through tandem [3 + 2] cycloaddition and C–C coupling processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf87b57d68e134d90e469faeb2a4cb75 https://doi.org/10.1039/d0qo01657h Zobrazit plný text záznamu