Acid blocking medication usage pre and post liver transplantation
| Autor: | Jaime Aranda-Michel, Sami R. Achem, C. Jean-Pierre, K. De Vault, Kelly Norman, Rolland C. Dickson, Hugo Bonatti, J. Slocum, Justin H. Nguyen, Ronald A. Hinder, John A. Stauffer, J. Gusler |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry medicine.drug_class medicine.medical_treatment Proton-pump inhibitor Liver transplantation medicine.disease Gastroenterology Liver disease Sirolimus Internal medicine medicine GERD Surgery Gastritis medicine.symptom business medicine.drug Abdominal surgery |
| Zdroj: | European Surgery. 39:57-60 |
| ISSN: | 1682-4016 1682-8631 |
| DOI: | 10.1007/s10353-006-0302-4 |
| Popis: | BACKGROUND: Terminal liver disease is associated with upper gastrointestinal (GI) pathology. Following liver transplantation (LT), some immunosuppressive agents can cause GI complications. METHODS: We investigated the use of acid blocking medication (ABM) pre and post transplant in a series of 467 consecutive LTs in 402 individuals, which were performed from 1998 to 2001 at our center. RESULTS: A total of 41% of patients were given ABM pretransplant. All patients received proton pump inhibitors (PPIs) for 100 days per protocol. After a median follow up of 5 (range 1–8.1) years for 339 evaluate transplants, 64% of patients received ABM for peptic ulcer disease (n = 28), GERD (n = 50), dyspepsia/gastritis (n = 30), recurrent liver cirrhosis (n = 15) and prophylaxis if patients were maintained on steroids (n = 21), MMF (n = 17), Sirolimus (n = 9) or received biphosphonates for osteoporosis (n = 22). In a minority of cases no clear indication could be found. CONCLUSIONS: Upper GI diseases are common complications after LT and many LT recipients require long term ABM. |
| Databáze: | OpenAIRE |
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