Haemodynamics of the new beta-adrenergic antagonist LB 46 in man

Autor:	J. Heikkilä, M. H. Friok, K. Luomanmäki
Rok vydání:	1970
Předmět:	Pharmacology Chronotropic medicine.medical_specialty Cardiac output Supine position Beta-adrenergic blocking agent business.industry Heart malformation Haemodynamic response Antagonist General Medicine Internal medicine Anesthesia Heart rate Cardiology Medicine Pharmacology (medical) business
Zdroj:	Pharmacologia Clinica. 2:134-137
ISSN:	1432-1041 0031-6970
DOI:	10.1007/bf00420339
Popis:	A new beta-adrenergic antagonist, LB 46, was given intravenously in a dose of 0.01 mg/kg to ten patients with minor cardiac abnormalities. The haemodynamic response to the compound was evaluated both at rest and during exercise in supine position. At rest there was a modest reduction in heart rate and cardiac output; a decrease in the maximal right ventricular dp/dt was the only indication of negative inotropy. More marked negative chronotropic and inotropy effects became apparent during exercise. No side-effects were observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf850d1a93e5f60c6822ea158e6a673c https://doi.org/10.1007/bf00420339 Zobrazit plný text záznamu Full text from SpringerLink