Synthesis of the novel chiral 1,3-amino alcohol 8-N,N-bis(ferrocenylmethyl)amino-menthol and its use as catalyst in the enantioselective addition of diethylzinc to aldehydes

Autor:	Pedro Molina, M. J. Vilaplana, Celia Andrés, Rafael Pedrosa, A. Arques
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Organic Chemistry Iodide Enantioselective synthesis Alcohol Optically active Diethylzinc Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Menthol
Zdroj:	Tetrahedron: Asymmetry. 13:5-8
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(02)00063-0
Popis:	Optically active 8-N,N-bis(ferrocenylmethyl)aminomenthol 5, obtained by condensation of (−)-aminomenthol with ferrocenecarboxaldehyde followed by N-alkylation with (ferrocenylmethyl)trimethylammonium iodide and further reduction, was found to catalyze (5 mol%) the enantioselective ethylation of aromatic, aliphatic and organometallic aldehydes to secondary alcohols with high enantioselectivities (up to 95%) at room temperature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf7d0862c5849ce24854f3ee88991a41 https://doi.org/10.1016/s0957-4166(02)00063-0 Zobrazit plný text záznamu Full Text from ScienceDirect