| Popis: |
Introduction: The exploration of pharmacological effect on Ayurvedic drugs are only possible through ani-mal experimentation. For the global acceptance of the Kasis Godanti Bhasma (KGB) - A herbo-mineral for-mulation of Ayurveda pharmaceutics, there is needs to revalidate the formulation on all aspects from its safety, efficacy, quality control and animal experimentation. Aims and Objectives: 1. To evaluate the effi-cacy of Kasis Godanti Bhasma 1st and 2nd in Pandu (Anemia). 2. To compare the effectiveness of Kasis Go-danti Bhasma 1st and Kasis Godanti Bhasma 2nd in Pandu (Anemia). Material and Methods: Anemia was induced by intra -peritoneal injection of Phenylhydrazine (PHZ) at 40 mg/kg for 2 days. Rats were divided in six groups of four rats each. The first group is the control group received distillated water. The second group is anemic control group received only Phenylhydrazine at 40 mg/kg for 2 days. Third and fourth groups received KGB 1st 500 mg/kg and 1000 mg/kg respectively. While fifth and sixth groups received KGB 2nd 500 mg/kg and 1000 mg/kg respectively. The vehicle and the Bhasmas were administered from day 2 to day 15 after Phenylhydrazine administration. Blood samples were collected from the orbital vein on day 0 before Phenylhydrazine administration, and on day 2, 7, 15 after Phenylhydrazine injection. Re-sult and Conclusion: Experimental study of KGB-1 and KGB-2 shows satisfactory result. On comparing result of KGB-1 and KGB-2. KGB-2 with both doses of 500 mg and 1000 mg shows significant result in anti-anemic effect. While in KGB-1, only 500 mg dose shows the significant result in anti-anemic effect. On comparing dose of both the samples 500 mg dose of KGB-1 and KGB-2 shows satisfactory result. |
