| Autor: |
Kathryn P. MacPherson, Malú G. Tansey, Amarallys F. Cintron, Maria Elizabeth de Sousa Rodrigues |
| Rok vydání: |
2018 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-12-811304-2.00016-x |
| Popis: |
This chapter provides an overview of the peripheral (nonbrain) and brain-immune mediators in brain health and neurodegenerative disease. We review the major immune cell types that contribute to the inflammatory environment in the brain, and mechanisms that regulate the blood–brain barrier. We also discuss the reasons for the paradigm shift that has brought the role of inflammation in age-related neurodegeneration to the forefront of contemporary research, as well as the role of peripheral inflammation in the establishment of a permissive environment for age-related neurodegeneration as a risk factor for diseases such as Parkinson’s and Alzheimer’s disease. We conclude with a discussion on the path forward toward therapeutic intervention: modulating immune cell trafficking to the brain, establishing second-hit models of neurodegenerative disease, and using deep immunophenotyping by flow cytometry to identify at-risk human populations with inflammatory endophenotypes as suitable candidates for immunomodulatory therapies in the treatment of age-related neurodegenerative disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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