Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

Autor:	Emeline Camand, Alexandre Benmerah, Mark G.H. Scott, Cédric Boularan, Stefano Marullo, Larissa Kotelevets, Lucien C.D. Gibson, Sandrine Etienne-Manneville, Evelyne Lima-Fernandes, Lamia Achour, George S. Baillie, Hervé Enslen, Eric Chastre, Julie A. Pitcher
Rok vydání:	2011
Předmět:	Scaffold protein RHOA General Immunology and Microbiology Beta-Arrestins General Neuroscience Cell migration Biology General Biochemistry Genetics and Molecular Biology Cell biology Lipid phosphatase activity Cancer research biology.protein PTEN Tensin Molecular Biology Protein kinase B
Zdroj:	The EMBO Journal. 30:2557-2568
ISSN:	0261-4189
Popis:	The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms. Despite its fundamental pathophysiological importance, how PTEN's cellular activity is regulated has only been partially elucidated. We report that the scaffolding proteins β-arrestins (β-arrs) are important regulators of PTEN. Downstream of receptor-activated RhoA/ROCK signalling, β-arrs activate the lipid phosphatase activity of PTEN to negatively regulate Akt and cell proliferation. In contrast, following wound-induced RhoA activation, β-arrs inhibit the lipid phosphatase-independent anti-migratory effects of PTEN. β-arrs can thus differentially control distinct functional outputs of PTEN important for cell proliferation and migration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf66b2557416bdc8cd9b544d2dfd7766 https://doi.org/10.1038/emboj.2011.178 Zobrazit plný text záznamu Plný text