Decreased excitability of the distal motor nerve of young patients with type 1 diabetes mellitus
| Autor: | B Özcan, Henk-Jan Aanstoot, Erwin Birnie, J.C. van der Heyden, Ifm de Coo, Joleen H. Blok, Henk J. Veeze, P van der Meer, GH Visser, M. Castro Cabezas |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Type 1 diabetes
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Axonal loss Motor nerve medicine.disease Surgery Compound muscle action potential Peripheral neuropathy medicine.anatomical_structure Internal medicine Pediatrics Perinatology and Child Health Internal Medicine medicine Cardiology business Peripheral Motor Neuropathy Subclinical infection Reinnervation |
| Zdroj: | Pediatric Diabetes. 14:519-525 |
| ISSN: | 1399-543X |
| DOI: | 10.1111/pedi.12048 |
| Popis: | __Abstract__ __Objective__: The compound muscle action potential (CMAP) scan is a novel neurophysiological technique that appears more sensitive in detecting peripheral motor neuropathy than conventional methods. This study explores the value of the CMAP scan for the detection of subclinical diabetic peripheral motor neuropathy. __Methods__: In this cross-sectional pilot study, CMAP scanning of the peroneal nerve was performed in (i) 13 well-controlled patients (8–25 yr old) with type 1 diabetes mellitus (T1DM) duration between 2.5 and 5 yr; (ii) 17 patients (10–25 yr old) with a duration of T1DM of at least 10 yr, poorly controlled and/or with microvascular complications and (iii) 13 adults with T1DM and established clinical diabetic peripheral neuropathy (DPN). Various CMAP scan variables, including measures of axonal excitability and axonal loss and reinnervation, were compared between patients and healthy controls. __Results__: Axonal excitability was significantly decreased in the young patient groups as compared to their controls. The CMAP scan measures of axonal loss and reinnervation differed only between patients with clinical DPN and their controls. __Conclusions__: Motor nerve axonal excitability seems to be reduced early in T1DM, even in well-controlled young patients, and probably before (irreversible) axonal damage occurs. These changes can be measured by the CMAP scan, which makes this a promising tool for detecting nerve dysfunction in T1DM. |
| Databáze: | OpenAIRE |
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