Fibrinogen Reduction During Selective Plasma Exchange due to Membrane Fouling
| Autor: | Yurie Hashimoto, Ayako Itagaki, Hiroko Yamamoto, Satoko Miyamoto, Tomokazu Okado, Soichiro Iimori, Hiroshi Seshima, Tatemitsu Rai, Eisei Sohara, Naoki Kurashima, Takuma Maeda, Motoki Yamamoto, Shigeto Komori, Shinichi Uchida, Atsushi Ohkubo, Shotaro Naito |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Chromatography
Fouling business.industry Scanning electron microscope Membrane fouling 030232 urology & nephrology Hematology 030204 cardiovascular system & hematology Fibrinogen law.invention 03 medical and health sciences 0302 clinical medicine Volume (thermodynamics) Biochemistry Nephrology Hollow fiber membrane law Sieving coefficient Medicine business Filtration medicine.drug |
| Zdroj: | Therapeutic Apheresis and Dialysis. 21:232-237 |
| ISSN: | 1744-9979 |
| Popis: | Fibrinogen is substantially reduced by most plasmapheresis modalities but retained in selective plasma exchange using Evacure EC-4A10 (EC-4A). Although EC-4A's fibrinogen sieving coefficient is 0, a session of selective plasma exchange reduced fibrinogen by approximately 19%. Here, we investigated sieving coefficient in five patients. When the mean processed plasma volume was 1.15 × plasma volume, the mean reduction of fibrinogen during selective plasma exchange was approximately 15%. Fibrinogen sieving coefficient was 0 when the processed plasma volume was 1.0 L, increasing to 0.07 when the processed plasma volume was 3.0 L, with a mean of 0.03 during selective plasma exchange. When fibrinogen sieving coefficient was 0, selective plasma exchange reduced fibrinogen by approximately 10%. Scanning electron microscopy images revealed internal fouling of EC-4A's hollow fiber membrane by substances such as fibrinogen fibrils. Thus, fibrinogen reduction by selective plasma exchange may be predominantly caused by membrane fouling rather than filtration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text