The Platelet Aggregation Score and Its Correlation to β- Thromboglobulin and Platelet Factor 4 Levels
| Autor: | Karen F. Marcoe, Lester R. Sauvage, Harvey S. Schiller, Svetlana Kaplan, Sherif El-Massry, Alexander Kaplan, Llod D. Fisher, Paul V. Roby, Gerge O. Gey |
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| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Platelet aggregation business.industry Hematology General Medicine 030204 cardiovascular system & hematology Correlation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Secretory protein Internal medicine Immunology medicine Platelet business Platelet factor 4 |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 1:135-141 |
| ISSN: | 1938-2723 1076-0296 |
| DOI: | 10.1177/107602969500100206 |
| Popis: | We describe a new method of interpreting platelet aggregometry results and its correlation to platelet secretory protein levels. We studied 123 healthy male volunteers, 37-85 years of age. The aggregation response to 2.5 μM ADP was measured in a standardized platelet suspension (SPS) prepared from platelet-rich plasma. Turbidimetic measurements included amplitude of the primary aggregation wave (Amp1), maximum aggregation amplitude (Amax), and area under the aggregation curve (Sagg). A platelet aggregation (PA) score was calculated as ( Amp1 /Amax) ·Sagg ·(whole-blood platelet count/SPS platelet count). β-Thromboglobulin (β-TG)and . platelet factor 4 (PF4) levels were measured by radioimmunoassay. The PA score correlated significantly (p < 0.0001) with β-TG ( r = 0.86) and PF4 ( r = 0.87). It was concluded that the PA score correlates closely with individual subjects' propensities to platelet activation, as reflected by plasma β-TG and PF4 levels. Key Words: Platelets-Platelet aggregometry-Platelet secretory proteins. |
| Databáze: | OpenAIRE |
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