CD28neg. T lymphocytes of a melanoma patient harbor tumor immunity and a high frequency of germline-encoded and public TCRs
| Autor: | Karin Schilbach, Hisayoshi Hashimoto, Marco Sterk |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry T cell Immunology FOXP3 Natural killer T cell 03 medical and health sciences Interleukin 21 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Cytotoxic T cell IL-2 receptor Antigen-presenting cell business CD8 |
| Zdroj: | Immunologic Research. 66:79-86 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-017-8976-1 |
| Popis: | Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cytotoxic. In this study, we examined the T cell receptor (TCR) repertoire and complementarity-determining region 3 sequences of CD28neg. T cells in a melanoma patient with recurrent disease who achieved long-term disease-free status. As a result, the patient’s oligoclonal CD8+CD28neg. T cell compartment holds TCRs that are public and specific for Melan-A as well as several public TCRs reported for common viral antigens. While over 80% of his CD8+CD28neg. T cells expressed a cytotoxicity marker, CD57, only 0.01% of CD8+ CD28neg. T cells were positive for Foxp3. In conclusion, our results demonstrate that besides virus-specific also tumor-associated self-antigen targeting T cells accumulate in the CD28neg. compartment of the immunological memory. Since the patient is in ongoing complete remission for more than 9 years, CD8+CD28neg. T cells with the Melan-A-specific TCR might contribute to antitumor immunity in this patient. |
| Databáze: | OpenAIRE |
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