Distribution of lindane in plasma and brain after a single administration to cats
| Autor: | D. Agarwal, N. Satsangi, R. N. Khanna, Prakash K. Ray, M. Anand |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Single administration
medicine.medical_specialty CATS Chromatography Health Toxicology and Mutagenesis Metabolite Plasma levels Pollution chemistry.chemical_compound Myelin Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Environmental Chemistry Distribution (pharmacology) Lindane |
| Zdroj: | Toxicological & Environmental Chemistry. 15:51-58 |
| ISSN: | 1029-0486 0277-2248 |
| DOI: | 10.1080/02772248709357221 |
| Popis: | The distribution of lindane and its metabolites in the plasma and brain of the cats after 30 minutes, 1, 2, 4 and 8 hours of administration of lindane (2mg/kg, i.v.) was investigated. The compound distributes differentially in the CNS and this pattern changes with time. The pattern of distribution shows that although lindane concentration is higher in areas with a high myelin content, it disappears more rapidly from gray matter. The plasma levels were also high at 30 minutes interval and then gradually decreased. The rate of formation of the metabolite 2,4,6‐Trichlorophenol appeared to be maximum in the first 4 hours. The accumulation of the compound and its metabolite in brain during the experimental period was not evident. |
| Databáze: | OpenAIRE |
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