Circulating leptin and risk of pancreatic cancer: a pooled analysis of three cohorts (LB369)

Autor: Christina C. Newton, Eric J. Jacobs, Satu Männistö, Leticia Nogueira, Debra T. Silverman, Yuzhen Tao, Michael Pollak, Demetrius Albanes, Rachael Z. Stolzenberg-Solomon
Rok vydání: 2014
Předmět:
Zdroj: The FASEB Journal. 28
ISSN: 1530-6860
0892-6638
DOI: 10.1096/fasebj.28.1_supplement.lb369
Popis: Background: Diabetes, overweight and obesity are consistently associated with increased pancreatic cancer risk; however the underlying mechanism(s) is uncertain. Leptin is an adipokine important in metabolic regulation. Methods: We conducted a pooled nested case-control study of participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Trial (PLCO), Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), and Cancer Prevention Study II Nutrition (CPS-II) cohorts to investigate whether pre-diagnostic circulating leptin concentrations were associated with pancreatic cancer. In total, 759 incident pancreatic adenocarcinoma cases were included in this analysis (average follow-up 8.3 years, up to 20 years). Incidence density selected controls (n=1069) were matched to cases by cohort, age, sex, race, and date of blood draw. We used conditional logistic regression analysis to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) and sex-specific quintiles (Q) based on the distri...
Databáze: OpenAIRE
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