Aloe vera delays mortality, but does not attenuate kidney injury in septic mices
| Autor: | André Lopes Valente, Marcus Vinicius Henriques Brito, Renan Kleber Costa Teixeira, Vitor Nagai Yamaki, Daniel Haber Feijó, Denilson José Silva Feitosa Junior, Edson Yuzur Yasojima, Eduardo Henrique Herbster Gouveia, Luan Teles Ferreira de Carvalho |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Kidney biology business.industry Acute kidney injury General Medicine medicine.disease biology.organism_classification Gastroenterology Aloe vera Surgery Sepsis medicine.anatomical_structure Internal medicine Intensive care medicine Histopathology business Survival analysis Cause of death |
| Zdroj: | International Archives of Medicine. |
| ISSN: | 1755-7682 |
| Popis: | Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings: Twenty six mice were distributed into four groups: Sham - surgery simulation (N=5); Control - Cecal ligation and puncture was performed (N=7); Aloe - Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe - Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p 0.05). Conclusions: Aloe vera extracts delays mortality but does not attenuate kidney injury in sepsis induced by cecal ligation and puncture in mice. |
| Databáze: | OpenAIRE |
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