Voltage-dependent calcium currents in cultured frog skeletal myocytes

Autor:	G. A. Nasledov, V. I. Luk'yanenko, I. E. Katina
Rok vydání:	1995
Předmět:	medicine.medical_specialty Physiology Myogenesis General Neuroscience Kinetics Dihydropyridine chemistry.chemical_element Skeletal Muscle Fibers Calcium Skeletal Myocytes Tonic (physiology) Endocrinology chemistry Internal medicine medicine Biophysics Myocyte medicine.drug
Zdroj:	Neurophysiology. 26:36-39
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf01059991
Popis:	Voltage-dependent calcium currents (ICa) in cultured embryonic skeletal frog myocytes at the stages of development ranging from one to six days were studied using the whole-cell patch-clamp recording technique. Fast dihydropyridine (DHP)-nonsensitiveICa and slow DHP-sensitiveICa were recorded during the early stages of myogenesis. These currents do not differ in their kinetics from theICa found in the adult frog muscle. Two slow voltage-dependent DHP-sensitiveICa were found. In terms of its activation time, the first slow ICa is similar toICa described in phasic skeletal muscle fibers. The second slowICa observed in about 10% of cells examined is similar toICa described in tonic skeletal muscle fibers of adult frog. In some cases, two slow currents with different kinetics were recorded in the same myocyte.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf33554b6ab71e0eaf73f4fa0e953706 https://doi.org/10.1007/bf01059991 Zobrazit plný text záznamu Full text from SpringerLink