Synthesis of γ-Butyrolactones, Quinoxalines, and Azauracils from 4-Aryl-2-oxobutanoic Acid Derivatives

Autor:	G. H. Labib, E. S. H. El-Ashry, A. I. El-Massry, Y. El-Kilany, M. Abdel Rahman
Rok vydání:	1988
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Bicyclic molecule chemistry Aryl Lactam Organic chemistry Aldol condensation General Chemistry Condensation reaction Aldehyde Lactone Reversible reaction
Zdroj:	Bulletin of the Chemical Society of Japan. 61:4427-4430
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.61.4427
Popis:	4-Aralkyl-5-aryl-3-hydroxy-2(5H)-furanones (2) have been prepared from the corresponding 4-aryl-2-oxobutanoic acids (1). The anticipated products from the reaction of the furanones (2) with o-phenylenediamine (3) have not been isolated, but products resulting from the condensation followed by retro-aldol type of reaction are obtained and determined as 3-(2-arylethyl)-2(1H)-quinoxalinones (4). Compounds 4 could be readily obtained by the condensation of 3 with 1. 4-Aryl-2-oxobutanoic acid thiosemicarbazones (5) have been cyclized to 5-(2-arylethyl)-6-azauracils (6).
Databáze:	OpenAIRE
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