Natural killer expansion, human leukocyte antigens‐ E expression and CD 14 + CD 56 + monocytes in a myelodysplastic syndrome patient

Autor:	Giuseppe Terrazzano, Mariangela Annunziatella, Giuseppina Ruggiero, Valentina Rubino, Orsola Vitagliano, Anna Teresa Palatucci, Angela Giovazzino, Fiorella Alfinito
Rok vydání:	2013
Předmět:	Ineffective Hematopoiesis Acute leukemia Myelodysplastic syndromes CD14 Hematology General Medicine Human leukocyte antigen Biology Natural killer T cell medicine.disease medicine.anatomical_structure hemic and lymphatic diseases Immunology medicine Bone marrow Stem cell
Zdroj:	European Journal of Haematology. 91:265-269
ISSN:	1600-0609 0902-4441
DOI:	10.1111/ejh.12152
Popis:	Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14(+) CD56(+) monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14(+) CD56(+) monocytes in BM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bf1a8c7deb07d5f0cb8f768c035c5614 https://doi.org/10.1111/ejh.12152 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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