Acute Myelogenous Leukemia Presenting with Bulky Lymphadenopathy

Autor:	Bruce A. Robbins, Russell Gollard, Alan Saven, Lawrence D. Piro
Rok vydání:	1996
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test Auer rod business.industry Lymphoblastic lymphoma Lymph node biopsy Myeloid leukemia Hematology General Medicine medicine.disease Lymphoma Leukemia Myelogenous hemic and lymphatic diseases medicine business Generalized lymphadenopathy
Zdroj:	Acta Haematologica. 95:129-134
ISSN:	1421-9662 0001-5792
DOI:	10.1159/000203861
Popis:	We report a patient with acute myeloid leukemia (AML) presenting with generalized lymphadenopathy, clinically simulating aggressive non-Hodgkin’s lymphoma. This patient presented with anemia and bulky lymphadenopathy in the oropharyngeal (Waldeyer’s ring), submandibular, supraclavicular and inguinal nodal regions. Lymph node biopsy was initially suggestive of a T-cell lymphoblastic lymphoma, based on morphologic features together with positive immunohistochemical staining for CD7 and CD43 (Leu 22). Definitive diagnosis of AML was established when a more detailed immunophenotypic analysis showed expression of the myeloid markers CD13 and CD33, and by the demonstration of rare Auer rods and positive peroxidase staining in bone marrow blast cells. Although this is a rare presentation, AML must always be considered in the clinical and pathologic differential diagnosis of aggressive non-Hodgkin’s lymphoma.
Databáze:	OpenAIRE
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