The use of carbamazepine to expedite the metabolism of a long‐acting aripiprazole injection

Autor:	Archana Jhawar, Michael A Riddle, Samantha Socco
Rok vydání:	2021
Předmět:	Pharmacology Fluphenazine Drug Psychosis business.industry viruses media_common.quotation_subject virus diseases Schizoaffective disorder Carbamazepine Drug interaction medicine.disease Regimen immune system diseases medicine Pharmacology (medical) Aripiprazole business medicine.drug media_common
Zdroj:	Journal of Clinical Pharmacy and Therapeutics. 47:562-566
ISSN:	1365-2710 0269-4727
Popis:	What is known and objective Long-acting injectable (LAI) antipsychotics are an integral part of mental health treatment. Modifying an LAI regimen poses several challenges because of the extended half-life of the drug. Case summary An acutely psychotic patient with schizoaffective disorder received aripiprazole lauroxil without resolution of symptoms. She was started on a previously successful regimen of oral fluphenazine. Due to continued psychosis, oral carbamazepine was initiated to expedite the LAI's metabolism allowing subsequent doses of fluphenazine to impart activity. What is new and conclusion Potent cytochrome enzyme inducers may help in transitioning patients from LAI antipsychotics to other therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bef327c108b186b83acc15357f5e0a0e https://doi.org/10.1111/jcpt.13563 Zobrazit plný text záznamu