Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides
| Autor: | Ji Fa Marshall Ong, Hui Chin Goh, Hartono Candra, Pui Yi Yung, Lik Tong Tan, Ma Yadanar Phyo, Jun Xian Goh, Siew Herng Chan, Chi Ying Gary Ding |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Absolute configuration Pharmaceutical Science 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Prenylation Drug Discovery Ic50 values Molecular Medicine Inhibitory concentration 50 Symploca hydnoides Cancer cell lines Spectroscopy Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products. 82:3482-3488 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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