Formulation and Characterization of Nanoparticles Loaded with Cefadroxil
| Autor: | C. N Hemalatha, Yeswanth Prasanna B Kumar, Vijey M Anandhi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Acrylate Nanoparticle Eudragit RL Polymer Biodegradable polymer Synthetic polymer Characterization (materials science) chemistry.chemical_compound Chemical engineering chemistry Cefadroxil medicine Pharmacology (medical) Pharmacology Toxicology and Pharmaceutics (miscellaneous) medicine.drug Biomedical engineering |
| Zdroj: | Research Journal of Pharmacy and Technology. 10:183 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2017.00040.3 |
| Popis: | Nanotechnology encompass a range of techniques rather than a single discipline and stretches across the whole spectrum of science, touching medicines, physics, engineering and chemistry. Targeted delivery of ingredients to a particular cell type or receptor. Capable of heat triggered local release. Nanoparticles are made up of non-biodegradable polymers such as methylmethacrylate or it can also be made from biodegradable polymers such as alkylcyano acrylate and albumin. Numerous methods exist for the manufacture of preparation of nanoparticles, allowing extensive modulation of their structure, composition and physiochemical properties. Formulation of nanoparticles of Cefadroxil using Albumin and Eudragit RL 100 in the ratios 1:1 and 1:2. Characterization of nanoparticles and invitro release of drugs has been carried out. In vitro release studies of each polymer was evaluated the synthetic polymer was exhibiting more extended release than natural polymer and the proportion have its influence in extending the release rate of the drug. The half-life of drug using Albumin loaded is 4hr and using Eudragit RL 100 is 4-5hr. Anti-bacterial studies has been done to confirm the anti-bacterial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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