Synthesis of phenylalkyl-substituted polyhydroxypiperidines as potent inhibitors for α-l-fucosidase

Autor:	Shota Miyawaki, Kenji Sugimoto, Toru Okaki, Yasuhiro Tezuka, Atsushi Kato, Daishiro Minato, Yuji Matsuya, Kasumi Sato, Osamu Onomura, Akiko Kamori, Shohei Ifuku, Tomoki Saka, Peter G. Kiria, Isao Adachi, Naoki Toyooka, Yukiko Yamashita
Rok vydání:	2013
Předmět:	chemistry.chemical_compound biology Chemistry Stereochemistry Organic Chemistry Drug Discovery biology.protein Iminosugar α l fucosidase Fucosidase Biochemistry IC50 Derivative (chemistry)
Zdroj:	Tetrahedron. 69:10653-10661
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.10.006
Popis:	Synthesis and inhibitory activities against α- l -fucosidase of phenylalkyl-substituted polyhydroxypiperidines have been described. Among the newly synthesized compounds, 2,4,6-trichloro derivative (16q) showed very high inhibitory activity against α- l -fucosidase with IC50 value of 0.005 μM, and Ki values of 0.0011 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::beb11fcb328cf4daafb39897642ce556 https://doi.org/10.1016/j.tet.2013.10.006 Zobrazit plný text záznamu Full Text from ScienceDirect