PERSISTENT SHEDDING OF WEST NILE VIRUS IN URINE OF EXPERIMENTALLY INFECTED HAMSTERS

Autor:	Robert B. Tesh, Marina Siirin, Hongli Chen, Amelia P.A. Travassos Da Rosa, Jessica H. Tonry, Shu-Yuan Xiao
Rok vydání:	2005
Předmět:	West Nile virus viruses Kidney pathology virus diseases Urine Biology medicine.disease_cause biology.organism_classification Virology nervous system diseases Infectious Diseases Antigen Viral replication Immunology medicine Immunohistochemistry Parasitology Viral shedding Mesocricetus
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 72:320-324
ISSN:	1476-1645 0002-9637
Popis:	Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bea7f89b1ca4c43c73f8f46e7e48ab6a https://doi.org/10.4269/ajtmh.2005.72.320 Zobrazit plný text záznamu