| Autor: |
Sunil Kumar Mishra, Vaibhav Mishra, Gautam Palit, Anil Kumar Pandey, Akanksha Srivastava, CKM Tripathi, Snober S. Mir, Abbas Ali Mahdi, Santosh Kumar Agarwal, Vijai Lakshmi |
| Rok vydání: |
2014 |
| Zdroj: |
The Journal of Phytopharmacology. 3:09-15 |
| ISSN: |
2320-480X |
| Popis: |
Context: In our previous study we have suggested that Rohitukine attenuates gastric mucosal injury; however its exact mechanism has not yet been established. Objective: The aim of present study was to evaluate the gastro protective mechanism of Rohitukine. Materials and methods: Sprague dawley rats and guinea pigs weighing 180–200 g were used. Dudenol ulcer was observed through Histamine induced gastric ulcer in guinea pigs. Result and Discussion: The present study was considered to evaluate the anti-ulcerogenic properties of an alkaloid chromane, Rohitukine from Dysoxylum binectariferum. Moreover, we studied the role of Rohitukine on the cytosolic concentration of cAMP and Histamine level in parietal cell-enriched cell suspension in order to ascertain its mechanism of action. In addition, Rohitukine failed to show protection in histamine induced gastric ulcer. Conclusion: Our docking study revealed that Rohitukine moderately bind with CCK2 receptor with binding energy as compare with standard drug benzotript. Furthermore, anti-secretory mechanism of Rohitukine mediated apparently through bind with CCK2 and inhibited the acid secretion, is novel to our finding. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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