A novel 1050nm handheld OCT imaging system for pediatric retinoblastoma patients: translation from laboratory bench to clinical study (Conference Presentation)
| Autor: | Oleg Nadiarnykh, Annette C. Moll, Johannes F. de Boer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
genetic structures
medicine.diagnostic_test business.industry Retinoblastoma Diagnostic tools medicine.disease eye diseases law.invention Lens (optics) Clinical study Optics medicine.anatomical_structure Optical coherence tomography law medicine sense organs Choroid Clinical imaging business Retinal scan Biomedical engineering |
| Zdroj: | Ophthalmic Technologies XXVI. |
| DOI: | 10.1117/12.2213150 |
| Popis: | We demonstrate a novel optical coherence tomography system specifically developed and validated for clinical imaging of retinoblastoma tumors in pediatric patients. The existing treatment options for this malignant tumor of the retina aim at reduction of tumor (re)growth risks, and vision preservation. The choice of optimal treatment strongly depends on skilled and detailed clinical assessment. Currently, the patients at risk are periodically monitored with retinal imaging for possible morphological changes over time, and new tumor seedings, as the existing real-time diagnostic tools are limited. Three-dimensional visualization of tissue layer and microvasculature at improved axial and lateral resolution of interference-based OCT imaging provides sensitivity for detection of vital tumor tissue concurrent with local treatment. Our METC-approved system accommodates for the range of optical parameters of infants’ eyes, and uses the 1050nm wavelength to access the deeper choroid layers of retina. The prototype is designed for patients in supine position under general anesthesia, where ergonomic handheld module is connected to fiber-based optical setup via umbilical cord. The system conforms to clinical safety requirements, including fully isolated low-voltage electric circuit. Focusing is performed with a mechanically tunable lens, where resolution is 6 µm axially, and varies with focusing at 10-18µm laterally. We will present optical design, performance limitations, and results of the ongoing clinical study, including the increased OCT diagnostic sensitivity in three dimensions in comparison with the established clinical imaging modalities. We will discuss images of early, active, and treated tumors, as well as follow-up on patients after local and systemic treatments. |
| Databáze: | OpenAIRE |
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