3D bioprinting of multicellular scaffolds for osteochondral regeneration
| Autor: | Lei Chen, Jiang Chang, Zhiguang Huan, Chen Qin, Nan Ma, Hongshi Ma, Hui Zhuang, Jingge Ma, Meng Zhang, Chengtie Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
3D bioprinting Chemistry Mechanical Engineering Cartilage Regeneration (biology) Tissue reconstruction 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Chondrogenesis 01 natural sciences 0104 chemical sciences law.invention Multicellular organism medicine.anatomical_structure Mechanics of Materials law medicine General Materials Science 0210 nano-technology Dual function Biomedical engineering |
| Zdroj: | Materials Today. 49:68-84 |
| ISSN: | 1369-7021 |
| DOI: | 10.1016/j.mattod.2021.04.016 |
| Popis: | Regeneration of osteochondral tissue is of great potentialities in repairing severe osteochondral defects. However, anisotropic physiological characteristics and tissue linage difference make the regeneration of osteochondral tissue remain a huge challenge. Herein, a multicellular system based on a bilayered co-culture scaffold mimicking osteochondral tissues was successfully developed for an alternative of osteochondral regeneration via a 3D bioprinting strategy. The dual function of integrally repairing both cartilage and bone could be achieved by designing multiple-cells distribution and a cell-induced bioink containing bioceramic particles. As an important bioactive agent, the Li-Mg-Si bioceramics-containing bioink exhibited the function of simultaneously stimulating multiple cells for differentiation towards specific directions. The 3D bioprinted co-culture scaffolds showed the capacity for osteochondral tissue regeneration by inducing osteogenic and chondrogenic differentiation in vitro and accelerating the repair of severe osteochondral defects in vivo. This study offers a potential strategy for complex tissue reconstruction through bioprinting multiple tissue cells in combination of bioceramics-stimulating bioinks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect