| Autor: |
Michael Bebbington, Margaret Hüsler, Mark P. Johnson, Jack Rychik, Scott Adzick, Stephanie Mann, Holly L. Hedrick, R. Douglas Wilson |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Prenatal Diagnosis. 27:1123-1128 |
| ISSN: |
0197-3851 |
| DOI: |
10.1002/pd.1845 |
| Popis: |
Congenital lung malformation can easily be diagnosed by prenatal ultrasound. Associated extrapulmonary malformations such as heart defects and chromosomal aberrations are rare. Objective The objective of this study was to describe the natural history, outcome and other associated malformations in fetuses with lung lesions and an associated heart defect. Methods Retrospective analysis of 4 cases of prenatally diagnosed fetal CCAMs and hybrid lesions with an associated heart defect and review of 8 cases in the literature. Results At a single referral center 1.9% of the fetuses with Congenital cystic adenomatoid malformation (CCAM) were diagnosed with an associated heart defect. Seven of the total 12 cases (58%) reviewed had a conotruncal heart abnormality. Chromosomal abnormalities were found in 5 (42%) of the cases. Conclusion This retrospective review shows that karyotyping in fetal lung lesions with an associated heart defect or isolated large lung lesions is indicated. It also suggests that there is a subpopulation of fetuses with CCAMs who have conotruncal heart defects. This finding may suggest a common genetic background. Copyright © 2007 John Wiley & Sons, Ltd. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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