| Autor: |
Sofie Demeyer, Daan Dierickx, Thomas Tousseyn, Jan Cools, Kris Jacobs, Nicole Mentens, Marlies Vanden Bempt, Gregor Verhoef, C Graux, Lukas Marcelis, Philippe Gaulard, Koen Debackere, Laurence de Leval, Iwona Wlodarska, Olga Gielen, Michaël Broux, Lucienne Michaux |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we performed RNA-sequencing of 18 cases and validated results in an independent cohort of 37 PTCL cases. We identified FYN-TRAF3IP2, KHDRBS1-LCK and SIN3A-FOXO1 as new in-frame fusion transcripts, with FYN-TRAF3IP2 as a recurrent fusion detected in 8 of 55 cases. Using ex vivo and in vivo experiments, we demonstrate that FYN-TRAF3IP2 and KHDRBS1-LCK activate signaling pathways downstream of the T cell receptor (TCR) complex and confer therapeutic vulnerability to clinically available drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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