LncRNA SNHG15 Contributes to Immuno-Escape of Gastric Cancer Through Targeting miR141/PD-L1

Autor:	Abdul Malik, Kai Yin, Jianguo Qu, Min Gu, Jixiang Chen, Lei Cui, Sheng-Chun Dang
Rok vydání:	2020
Předmět:	0301 basic medicine Competing endogenous RNA Cancer Biology medicine.disease Programmed cell death ligand 1 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Oncology Downregulation and upregulation 030220 oncology & carcinogenesis PD-L1 Cancer cell Cancer research medicine biology.protein Pharmacology (medical) Stomach cancer
Zdroj:	OncoTargets and Therapy. 13:8547-8556
ISSN:	1178-6930
DOI:	10.2147/ott.s251625
Popis:	Introduction Long non-coding RNAs (lncRNAs) have been demonstrated to participate in many biological processes and severs as important regulators during the progression of gastric cancer. Methods Here, we introduced human lncRNA SNHG15 which was highly expressed in gastric cancer and cells. Interestingly, the expression of SNHG15 was correlated with programmed cell death ligand 1 (PD-L1), which promotes the resistance of gastric cancer cells to immune responses. Meanwhile, SNHG15 downregulation suppressed the expression of PD-L1 and resistance of immune responses. Results Further, our results suggested that SNHG15 acted as a competing endogenous RNA (CeRNA) to sponge miR-141, which was downregulated in gastric cancers and negatively correlated to PD-L1. Conclusion Our results suggested that SNHG15 improved the expression of PD-L1 by inhibiting miR-141, which in turn promoted the resistance of stomach cancer cells to the immune responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be8d3b6b1c1652ebe6cc515048dc9096 https://doi.org/10.2147/ott.s251625 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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