NMR Relaxation Study of Cholesterol Binding with Plant Metabolites

Autor:	O. Yu. Gluschenko, N. E. Polyakov, T. V. Leshina
Rok vydání:	2011
Předmět:	chemistry.chemical_compound Ozonolysis Membrane Stability constants of complexes Chemistry Computational chemistry Cholesterol Metabolite Kinetics Cholesterol binding Organic chemistry Atomic and Molecular Physics and Optics Stoichiometry
Zdroj:	Applied Magnetic Resonance. 41:283-294
ISSN:	1613-7507 0937-9347
Popis:	Nuclear magnetic resonance relaxation technique has been applied to study the interaction of cholesterol and its oxidation products with plant metabolite, glycyrrhizic acid. In all cases, the decay kinetics of echo signal shows bi-exponential behavior. It was demonstrated that the fast component of the decay kinetics belongs to the complex with stoichiometry of 1:2. The stability constants and thermodynamic parameters of these complexes have been measured. We propose that the complexation with glycyrrhizic acid could be an effective approach to regulate the cholesterol level inside and outside of cage membranes. In addition, the importance of this approach as a tool for reducing the cytotoxicity of the oxidation products of cholesterol is under discussion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be8bb209334dc895b77d8d9107db1690 https://doi.org/10.1007/s00723-011-0258-9 Zobrazit plný text záznamu Full text from SpringerLink