REVERSED PHASE LIQUID CHROMATOGRAPHIC DETERMINATION OF MELOXICAM IN HUMAN PLASMA AND ITS PHARMACOKINETIC APPLICATION

Autor:	N. Foda, A. Abd El-Bary, M. Elkhateeb
Rok vydání:	2001
Předmět:	Chromatography Chemistry Calibration curve Coefficient of variation Biochemistry (medical) Clinical Biochemistry Extraction (chemistry) Reversed-phase chromatography Biochemistry High-performance liquid chromatography Analytical Chemistry Meloxicam chemistry.chemical_compound Electrochemistry medicine Quantitative analysis (chemistry) Phosphoric acid Spectroscopy medicine.drug
Zdroj:	Analytical Letters. 34:1175-1187
ISSN:	1532-236X 0003-2719
DOI:	10.1081/al-100104963
Popis:	A simple, rapid, specific and reliable high performance liquid chromatographic assay of meloxicam in human plasma has been developed. Reversed phase chromatography was conducted using a mobile phase of methanol:phosphate buffer (60:40) V/V, pH 3.2, adjusted with phosphoric acid, UV detection at 346 nm. The drug after extraction from plasma was chromatographed using a C18 reversed phase analytical column. The average recoveries of Meloxicam from spiked plasma in the concentration range from (0.04–0.8) μg/ml was 93.33% and their respective CV was 2.86%. Regression analysis for the calibration plot for plasma standards obtained on three different days for the drug concentrations between (0.04–0.8)μg/ml indicated excellent linearity (r > 0.9996) and the coefficient of variation of the slopes of the three lines was 0.01). The high correlation coefficients and the similarities in the sl...
Databáze:	OpenAIRE
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