The Effect of Mechanical Compatibility and of Thrombogenicity on the Ingrowth of a New Synthetic Vascular Prosthesis (Experimental Study)

Autor:	Yuriy M. Tsygankov, A. D. Shepelev, A. A. Sergeev, S. V. Krasheninnikov, Leo A. Bockeria, T. Kh. Tenchurin, A. Yu. Gorodkov, Sh. T. Zhorzholiani, A. V. Agafonov
Rok vydání:	2021
Předmět:	Aortography Materials science medicine.diagnostic_test Infrarenal aorta medicine.medical_treatment Biophysics Thrombogenicity General Chemistry General Medicine Biochemistry Prosthesis Compatibility (mechanics) medicine Vascular prosthesis Biomedical engineering Histological examination
Zdroj:	Doklady Biochemistry and Biophysics. 500:317-320
ISSN:	1608-3091 1607-6729
DOI:	10.1134/s1607672921050185
Popis:	Common disadvantages of modern synthetic vascular prostheses are thrombogenicity and lack of biomechanical compatibility with the prothesized vessel. To elucidate the role of these factors in the prosthesis integration, prostheses specimens were made by the electrospinning from the known materials: polycaprolactone, polyurethane and a mixture of fluorine-containing synthetic rubber FKM-26 with fluoroplastic F-26. The germination of the prostheses was compared with standard e-PTFE prosthesis in the pigs infrarenal aorta. The elastic properties of prostheses were studied by elastometry under the physiological range of loads. The thrombogenicity of the materials was determined by the number of platelets adhered to material surface exposed to native blood. The patency of the prostheses was checked by aortography. The germination of prostheses was assessed in the histological examination. It was shown that, with this set of materials, biomechanical compatibility turned out to be a more important factor of integration than the material thrombogenicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be7df3398c6037c2ea9d4d1fe1758bbc https://doi.org/10.1134/s1607672921050185 Zobrazit plný text záznamu Plný text ve formátu PDF