ChemInform Abstract: Methylation of Some Deprotonated Sterically Hindered Pyrimidin-4-ols

Autor:	G. P. Savage, R. F. Evans
Rok vydání:	2010
Předmět:	Steric effects chemistry.chemical_compound Deprotonation chemistry Stereochemistry Substituent chemistry.chemical_element General Medicine Methylation Ring (chemistry) Nitrogen
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199221198
Popis:	Anions derived from t-butyl-substituted pyrimidin-4-ols were methylated with iodomethane . The site of methylation was determined by proton-coupled 13C n.m.r. and the relative proportions of isomers were determined by 1H n.m.r. A t-butyl substituent ortho to a ring nitrogen markedly reduced the propensity for methylation at that nitrogen to the point where O-methylation, uncommon under these conditions, was observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be7c2d4b7b3e478af66d0e1fe8a5656e https://doi.org/10.1002/chin.199221198 Zobrazit plný text záznamu Plný text