Synthesis of (–)-Convolutamydine a Derivatives and Analogs

Autor:	Natalia Sucman, Alic Barba, Fliur Macaev, D. Ya. Bilan, I. P. Dragalin, O. M. Radul
Rok vydání:	2021
Předmět:	Stereochemistry Chemistry Plant Science General Chemistry Conjugated system Cytotoxicity Linker General Biochemistry Genetics and Molecular Biology
Zdroj:	Chemistry of Natural Compounds. 57:516-520
ISSN:	1573-8388 0009-3130
Popis:	Symmetric and asymmetric derivatives of (–)-convolutamydine and analogs in which 3-hydroxy-2-oxindole fragments were conjugated through a 2-oxopropyl linker were synthesized. Monobromoxindole 10 from the reaction of (S)-3-hydroxy-3-(2-oxopropyl)indolin-2-one and 5-bromoisatin exhibited the greatest cytotoxicity of all tested compounds with CC50 = 0.197 mM in acutely infected MT-4 cells. The cytotoxicities of dibromo derivatives 7 and 9 decreased as compared to 10 to CC50 = 0.205 and 0.245 mM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be7a33165158f1fc93c29bca37d7c678 https://doi.org/10.1007/s10600-021-03400-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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