| Popis: |
During the recent years, we published some articles on gamma correction medical imaging, gamma correction 99mTc-HDP pinhole bone scan (GCPBS) in particular, for the specific diagnosis of callused trabecular microfracture (CTMF), bone contusion, and bone marrow edema and hemorrhage (Bahk et al. 2010, 2016, 2017, 2019). Those studies showed that the high 99mTc-HDP uptake in contused trabeculae is not suppressed by gamma correction, but the low uptake in intact bone trabeculae and edema and the moderate uptake in hemorrhage was cleanly suppressed. Originally, Francis et al. (1980) noted in their Sprague-Dawley rat experiment that 99mTc-HDP uptake was significantly increased in injured trabeculae because bone tracer was actively adsorbed onto amorphous calcium phosphate, which is actively engaged with osteoneogenesis in osteoblastic rimming of contused trabeculae. It was also shown that the nominal tracer uptake in intact bone and mild to moderate tracer uptake in bone edema and hemorrhage is due to loose adhesion of tracer onto crystalline hydroxyapatite. Recently, we also performed young rat experiment and confirmed the fact that the nominal tracer uptake in the normal trabeculae and mild to moderate tracer uptake (Fig. 4.1) in edema and hemorrhage are all cleanly suppressed by gamma correction, but the high uptake in CTMF is not suppressed at all (Fig. 4.2) (Bahk et al. 2016). To be exact the normal control study showed that the intact femur uniformly accumulates mild tracer, which is neatly suppressed by gamma correction barely showing endosteum on H&E stain (Fig. 4.1). Contrary, however, when trabeculae are well defined after gamma correction it may well denote that endosteal rimming is formed (Fig. 4.2). Unsuppressed high tracer uptake in epiphysis indicates that the physis in young rats is actively engaged with physiologically growing osteoneogenesis. The same biophysical phenomenon can be seen in CTMF, which is similarly engaged with active repair osteoneogenesis. It can be said that distinctly defined trabeculae may well be interpreted to designate endosteal rimming (Fig. 4.2). |
