Inhibition of leukemia cell growth under magnetic fields of up to 8 T
| Autor: | Masakazu Iwasaka, M. Ogiue-Ikeda, Hiroko Kotani, S. Ueno, Y. Sato |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Air volume
Cell growth Magnetic field exposure chemistry.chemical_element equipment and supplies medicine.disease Oxygen Electronic Optical and Magnetic Materials Magnetic field Laboratory flask Leukemia Nuclear magnetic resonance chemistry Biophysics medicine Cell medium Electrical and Electronic Engineering human activities |
| Zdroj: | IEEE Transactions on Magnetics. 37:2912-2914 |
| ISSN: | 0018-9464 |
| DOI: | 10.1109/20.951345 |
| Popis: | In the present study, we investigated whether strong magnetic fields affect the growth of leukemia cells. We used a horizontal type of superconducting magnet, which produced magnetic fields of up to 8 T at its center. Leukemia cells (TCC-S) were seeded in 40 ml flasks and incubated with and without magnetic field exposure for 5 days. TCC-S growth with magnetic field exposure was inhibited by 60/spl sim/80% compared with TCC-S growth without magnetic field exposure, only with an initial cell density of 2/spl times/10/sup 4/ cells/ml. To investigate the effect of air volume on leukemia cell growth, the volume of the medium was decreased. When the medium was exposed to a greater volume of air, an enhanced inhibition of leukemia cell growth was observed. The possible mechanism of the observed effects was a concentration change of dissolved oxygen in the cell medium. Redistribution of dissolved oxygen molecules might result in the lack of an essential amount of oxygen necessary for leukemia cell growth. |
| Databáze: | OpenAIRE |
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