Valeiridoside, an Iridoid Xyloside from Valeriana procera with Anxiogenic Effect in Mice

Autor: José Luis Balderas-López, José Carlos Tavares-Carvalho, Alejandro Alfaro-Romero, Andrés Navarrete
Rok vydání: 2021
Předmět:
Zdroj: Revista Brasileira de Farmacognosia. 31:85-90
ISSN: 1981-528X
DOI: 10.1007/s43450-021-00140-x
Popis: Valeriana procera Kunth, Caprifoliaceae, is a medicinal plant used in Mexican traditional medicine as a mild sedative, tranquilizer, and sleep-aid agent. This species possesses several pharmacological effects including sedative, anxiolytic, and vasorelaxant. The chemical investigation of this plant has led to the isolation of an iridoid xyloside from the ethanol extract prepared with roots which were named valeiridoside, a β-d-xyloside of the iridolactone patriscabrol. This compound, paradoxically, showed an anxiogenic effect in mice at 10 mg/kg (i.p.), which was inhibited by ketanserin (2.5 mg/kg, i.p.) and WAY 100635 (5 mg/kg, i.p.), but not for diazepam (2.5 mg/kg, i.p.) or NECA (0.00547 mg/kg, i.p.). These results suggest the participation of 5-HT2 and 5-HT1A serotonin receptors, but not the involvement of GABAA or adenosine receptors in the anxiogenic effect of valeiridoside.
Databáze: OpenAIRE