Kinetics of accumulation and elimination of [3H]rimantadine in tissues of pregnant mice and fetuses
| Autor: | N. F. Pravdina, V. M. Shobukhov, I. G. Petrova, S. G. Tul'kes, G. A. Galegov |
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| Rok vydání: | 1985 |
| Předmět: |
Melphalan
Strain (chemistry) medicine.drug_class Chemistry Antibiotics Radioimmunoassay Spleen General Medicine Drug resistance medicine.disease Molecular biology General Biochemistry Genetics and Molecular Biology Cryopreservation medicine.anatomical_structure immune system diseases medicine Plasmacytoma medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 99:90-92 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00806623 |
| Popis: | A sarcolysine-resistant strain of mouse plasmacytoma MOPC/406 was obtained in experiments on 250 BALB/c mice. The initial plasmacytoma strain is highly sensitive to sarcolysine. When administered in doses of 10 and 5 mg/kg it increases the lifespan up to 50 days (the observation period). In the course of resistance induction by incremental doses of sarcolysine, a highly resistant plasmacytoma strain was obtained. In the 20th generation of inoculations with the use of sarcolysine administration of 10 mg/kg (intraperitoneally) provided only a 18% increase in the lifespan, whereas the dose 5 mg/kg stimulated the growth of plasmacytoma. The strain obtained preserves its resistance under cryoconservation in liquid nitrogen, being a model that permits one to study resistance, cross-resistance and approaches to its overcoming. |
| Databáze: | OpenAIRE |
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