A first case of pregnant woman who contracted infection of indigenous genotype 3 hepatitis E virus in Japan

Autor:	Kuniko Miyamoto, Tatsuya Aikawa, Fumio Tsuda, Kunihiko Yamagata, Hiroaki Okamoto, Masaharu Takahashi
Rok vydání:	2009
Předmět:	Hepatitis Hepatology business.industry viruses virus diseases Hepatitis A medicine.disease Hepatitis E medicine.disease_cause Virology digestive system diseases Hepatitis E virus Genotype medicine Liver function Viral hepatitis business Acute hepatitis
Zdroj:	Kanzo. 50:163-165
ISSN:	1881-3593 0451-4203
DOI:	10.2957/kanzo.50.163
Popis:	A 35-year-old woman who was 14 weeks pregnant visited a gynecology hospital to undergo a surgical abortion. Although she was not jaundiced, and had no signs of hepatitis, liver function was abnormal (ALT, 100 IU/L; AST, 96 IU/L). The serum obtained was negative for markers of hepatitis A, B, and C viruses. However, based on the positive results of non-routine IgM/IgA anti-HEV and HEV RNA assays, the patient was occasionally diagnosed with sporadic acute hepatitis E. The HEV isolate recovered from the patient was phylogenetically close to known genotype 3 HEV strains circulating in Japan, with the highest identity of 93.2%. We believe that testing for hepatitis E should be routine in Japan, in cases of suspected viral hepatitis.
Databáze:	OpenAIRE
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