Developmental regulation of CYCA2s contributes to tissue-specific proliferation inArabidopsis
| Autor: | EunKyoung Lee, Fred D. Sack, Frederik Coppens, Marnik Vuylsteke, Enrico Scarpella, Steffen Vanneste, Tyler J. Donner, Erich Grotewold, Bert De Rybel, Gert Van Isterdael, Freya De Winter, Stijn Dhondt, Gerrit T.S. Beemster, Zidian Xie, Tom Beeckman, Jiří Friml, Dirk Inzé, Lieven De Veylder |
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| Rok vydání: | 2011 |
| Předmět: |
General Immunology and Microbiology
Cell division Cell growth General Neuroscience fungi Morphogenesis food and beverages Cell cycle Biology biology.organism_classification General Biochemistry Genetics and Molecular Biology Cell biology Multicellular organism Arabidopsis Molecular Biology Transcription factor Mitosis |
| Zdroj: | The EMBO Journal. 30:3430-3441 |
| ISSN: | 0261-4189 |
| DOI: | 10.1038/emboj.2011.240 |
| Popis: | In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development. |
| Databáze: | OpenAIRE |
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