5-Hydroxypentane-2,3-dione (laurencione), a bacterial metabolite of 1-deoxy-D- threo -pentulose

Autor:	Catherine Pale-Grosdemange, Michel Rohmer, Knut Danielsen, Luisa Maria Lois, Albert Boronat, Narciso Campos, Lionel Charon, Surya Rosa Putra
Rok vydání:	1998
Předmět:	Klebsiella biology Chemistry Stereochemistry Metabolite Organic Chemistry medicine.disease_cause biology.organism_classification Biochemistry chemistry.chemical_compound Drug Discovery medicine Escherichia coli Bacteria
Zdroj:	Tetrahedron Letters. 39:6185-6188
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01301-x
Popis:	Cell-free systems from the bacteria Escherichia coli and Klebsiella planticola that were incubated with 13 C labeled pyruvate and D-glyceraldehyde synthesized 5-hydroxypentane-2,3-dione (laurencione) along with 1-deoxy-D- threo -pentulose (1-deoxy-D-xylulose). Both compounds showed identical labeling patterns, indicating that the C 5 skeletons were derived from the condensation of (hydroxyethyl)thiamin on D-glyceraldehyde. Conversion of [5,5- 2 H 2 ]deoxyxylulose into laurencione by a cell-free system from E. coli showed that the α-dione is obtained from the pentulose by water elimination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be5243e186c9a7d93c73878271879989 https://doi.org/10.1016/s0040-4039(98)01301-x Zobrazit plný text záznamu Full Text from ScienceDirect