DEVELOPMENT OF HUMAN GROWTH HORMONE PRODUCED IN RECOMBINANT BACTERIA AS A THERAPEUTIC AGENT
| Autor: | B. Holmström, A. Wichman, A. Skottner-Lundin, B. Strindberg, K. Fhölenhag, H. Flodh, Linda Fryklund |
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| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Methionine biology Somatotropic cell Connective tissue Biological activity biology.organism_classification law.invention chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Biochemistry law Internal medicine medicine Recombinant DNA medicine.symptom Weight gain Bacteria Hormone |
| Popis: | Publisher Summary Human growth hormone ( hGH) is used therapeutically for the treatment of children with pituitary deficiency. The hormone is a protein of molecular weight 22,000, which is isolated from human pituitary glands. Although the present product is of excellent quality and efficacy, the supply of pituitaries is a limiting factor. The biosynthetic hGH appears to be identical to the pituitary hormone with regards to molecular weight and sequence with the exception of N-terminal methionine. No contaminating proteins or isohormones are present. Biological activity determined in hypophysectomized rats by increase in epiphysial width of tibia, weight gain, and sulfate incorporation into connective tissue appears to be identical to that of the pituitary hormone. |
| Databáze: | OpenAIRE |
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