MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment
| Autor: | Shu Juan Puang, Judy Sng, Tendy Ching, Bavani Elanggovan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system Environmental enrichment Dendritic spine Arc (protein) Neurite Biology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Synaptic plasticity Neuroplasticity Developmental plasticity Transcription factor 030217 neurology & neurosurgery |
| Zdroj: | Neuronal Signaling. 4 |
| ISSN: | 2059-6553 |
| DOI: | 10.1042/ns20190147 |
| Popis: | We investigated the effects of environmental enrichment during critical period of early postnatal life and how it interplays with the epigenome to affect experience-dependent visual cortical plasticity. Mice raised in an EE from birth to during CP have increased spine density and dendritic complexity in the visual cortex. EE upregulates synaptic plasticity genes, Arc and Egr1, and a transcription factor MEF2C. We also observed an increase in MEF2C binding to the promoters of Arc and Egr1. In addition, pups raised in EE show a reduction in HDAC5 and its binding to promoters of Mef2c, Arc and Egr1 genes. With an overexpression of Mef2c, neurite outgrowth increased in complexity. Our results suggest a possible underlying molecular mechanism of EE, acting through MEF2C and HDAC5, which drive Arc and Egr1. This could lead to the observed increased dendritic spine density and complexity induced by early EE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|