Bioactive Core–Shell CaF2 Upconversion Nanostructure for Promotion and Visualization of Engineered Bone Reconstruction
| Autor: | Yaping Du, Yingqian Wang, Yan Wei, Chunhua Yan, Rui Wang, Zhihao Li, Quan Yuan, Miusi Shi, Haoran Liu, Yufeng Zhang, Chenhui Ji |
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| Rok vydání: | 2020 |
| Předmět: |
Nanostructure
Chemistry Regeneration (biology) General Engineering General Physics and Astronomy Nanoprobe Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Regenerative medicine Photon upconversion 0104 chemical sciences Core shell Tissue engineering General Materials Science 0210 nano-technology Biomineralization |
| Zdroj: | ACS Nano. 14:16085-16095 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Inorganic ion metabolism plays significant roles in various life processes including signal transduction, substance exchange, and cellular constructions. Regulation and monitoring of ion metabolism offer great promise to modulate biological activities and provide insights into related mechanisms. Here, a synergistic nanodepot based on a bioactive core-shell CaF2 upconversion nanostructure that integrates multiple mineral ions for metabolic regulation was built for the acceleration and monitoring of the biomineralization process. Multiple mineral ions released from the nanodepots can accelerate the growth of inorganic crystals and enhance the production of organic matrixes, synergistically facilitating the regeneration of bone defects in vivo. During the process, such a nanodepot can be constructed to specifically recognize osteoblasts for the monitoring of biomineralization. This nanoprobe represents an efficient strategy to promote and monitor biomineralization-related metabolic activities with applications in fundamental research, disease diagnosis, and regenerative medicine. |
| Databáze: | OpenAIRE |
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