Chimiothérapie métronomique en oncologie pédiatrique : effet de mode ou espoir réel ?
| Autor: | Eddy Pasquier, J.-C. Gentet, J. Sterba, Jochen Rössler, Nicolas André, A. Verschuur |
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| Rok vydání: | 2009 |
| Předmět: |
Drug
Oncology medicine.medical_specialty Chemotherapy Angiogenesis business.industry media_common.quotation_subject medicine.medical_treatment Cancer Disease medicine.disease Metronomic Chemotherapy Pharmacotherapy Internal medicine Resistant cancer Pediatrics Perinatology and Child Health medicine business media_common |
| Zdroj: | Archives de Pédiatrie. 16:1158-1165 |
| ISSN: | 0929-693X |
| DOI: | 10.1016/j.arcped.2009.03.019 |
| Popis: | Angiogenesis is crucial for the growth of cancer. As such, it has become an established target in fighting cancer. Metronomic chemotherapy-the chronic administration of chemotherapy at relatively low, minimally toxic doses on a frequent schedule of administration at close regular intervals, with no prolonged drug-free breaks-is a potential novel approach to controlling advanced cancer disease. It is thought to work primarily through antiangiogenic mechanisms and has the property of killing resistant cancer cells while significantly reducing undesirable toxic side effects. We review the data regarding the use of metronomic chemotherapy in children with cancer and discuss its potential uses and limits. |
| Databáze: | OpenAIRE |
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