Spectroscopic investigation of tetracycline interaction with phospholipid Langmuir–Blodgett films

Autor:	Mila Nocentini, Filippo Gambinossi, Barbara Mecheri, Claudia Focardi, Gabriella Gabrielli, Gabriella Caminati, M. Puggelli
Rok vydání:	2002
Předmět:	Tetracycline Phospholipid Infrared spectroscopy Bioengineering Photochemistry Langmuir–Blodgett film Biomaterials Contact angle chemistry.chemical_compound Crystallography Ultraviolet visible spectroscopy chemistry Mechanics of Materials medicine Molecule Absorption (chemistry) medicine.drug
Zdroj:	Materials Science and Engineering: C. 22:301-305
ISSN:	0928-4931
DOI:	10.1016/s0928-4931(02)00217-5
Popis:	A widely used veterinary antibiotic, tetracycline (TC), has been incorporated in Langmuir–Blodgett (LB) films of dipalmitoylphosphatidic acid (DPPA) by means of two different procedures: co-transfer and incubation in solution. The resulting structures were characterized by means of contact angle and ellipsometric measurements. The presence of the antibiotic in the phospholipid film was evidenced by means of UV–Vis electronic absorption and infrared vibrational spectroscopy. The two sets of measurements unambiguously indicated the presence of the drug in the LB layer films obtained with both methods, although incubation led to a smaller content of immobilized tetracycline. In both cases, the drug was found to reside in the hydrophilic portion of the layers due to specific interactions of the dimethylamino group of the molecule with the polar head groups of the phospholipid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be3b809c30f2ec2bd1bd348af0f7cde9 https://doi.org/10.1016/s0928-4931(02)00217-5 Zobrazit plný text záznamu Full Text from ScienceDirect