Comparative Subchronic Inhalation Bioassay in Hamsters of a Cicarette that only Heats Tobacco

Autor:	H. S. Deford, Arnold T. Mosberg, Roger A. Renne, B. J. Greenspan, Ray L. Buschbom, Alfred P. Wehner, H. A. Ragan, A. W. Hayes, Gary T. Burger, Christopher R. E. Coggins, R. B. Mterberg, C. W. Wright
Rok vydání:	1990
Předmět:	Smoke Inhalation Chemistry Health Toxicology and Mutagenesis Physiology Clinical appearance Toxicology Smoke exposure chemistry.chemical_compound Respiratory flow Carboxyhemoglobin Bioassay Total particulate matter
Zdroj:	Inhalation Toxicology. 2:255-283
ISSN:	1091-7691 0895-8378
DOI:	10.3109/08958379009145258
Popis:	This subchronic inhalation study compared the effects of nose-only exposure in hamsters to the smoke from the University of Kentucky 1R4F reference cigarette, which burns tobacco, and a test cigarette, which only heats tobacco. Thirty-four Syrian golden hamsters per sex per group were exposed to either reference or test smoke at 0, 120, 350, or 640 pg wet total particulate matter (WTPM)/l of air, 1 h/day, 5 days/wk. Of these 34 hamsters, 9 hamsters/sex/group were evaluated for respiratory flow, blood carboxyhemoglobin, and plasma nicotine and coining during the first 12 wk of exposure and then killed. Another 75 of the 34 hamsters/sex/group were killed and evaluated after 13 wk of exposure (Basic Study); the remaining 10 hamsters/sex/group were held without smoke exposure for an additional 6 wk (Recovery Croup). Clinical appearance, mortality body and selected organ weights, and gross and histologic changes were examined in hamsters killed after 13 wk of exposure and 6 wk after cessation of exposu...
Databáze:	OpenAIRE
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