Why is the antibody response of Atlantic cod so poor? The search for a genetic explanation

Autor:	Lars Pilström, Gregory W. Warr, Siv Strömberg
Rok vydání:	2005
Předmět:	Immune system biology Infectious disease (medical specialty) Immunology biology.protein Gadus Immunogenetics Aquatic Science Antibody Immunoglobulin light chain biology.organism_classification Atlantic cod Major histocompatibility complex
Zdroj:	Fisheries Science. 71:961-971
ISSN:	1444-2906 0919-9268
Popis:	The immune system of the Atlantic cod (Gadus morhua L) is unusual in that it cannot produce a specific antibody response upon immunization. Despite this, the cod is not particularly susceptible to infectious disease in its normal environment. This review examines the potential genetic basis for the lack of a specific antibody response in the cod. The genetics of cod immunoglobulins are compared with those of other well-characterized teleost fish. A review of the evidence suggests that deficiencies in the number, structure, organization, diversity and expression of both Immunoglobulin (Ig) heavy and Ig light chain genes in cod cannot explain its unusual antibody response. It is concluded that a deficiency in cod major histocompatibility (MH) class II molecules is a prime suspect for the lack of a specific antibody response in cod, and that testing of this hypothesis must await future experimentation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be35f04b9978f8c101f0c5510b42c5fc https://doi.org/10.1111/j.1444-2906.2005.01052.x Zobrazit plný text záznamu Plný text ve formátu PDF